Brandon Santini

Award winning favorite kicks off HARMONICA WEEK at High Cotton! A 25-year veteran of the blues, rock & now country music circuits, Brandon Santini has built his sound from the Piedmont roots of his North Carolina childhood to the storied stages of Memphis’ Beale Street where he refined his playing into the explosive harmonica work, commanding voice, and dynamic stage presence & songwriting. He has earned eleven Blues Music Award nominations, landed major TV placements, and has a reputation as one of today’s leading modern blues performers. Not to mention that he has had the honor of performing on stage with Buddy Guy, Blues Traveler, Gary Clark Jr, Beth Hart, and Charlie Musselwhite — as well as recording with the iconic 60's rocker Sam The Sham, in 2011. Brandon Santini continues to build national momentum following the release of his latest album, Which Way Do We Go?, his most acclaimed project to date. The album earned him four nominations at the 2026 Blues Music Awards, recognizing his work as a songwriter, instrumentalist, and recording artist, and further cementing his place among today’s leading voices in modern blues. The album’s lead single, “Mile After Mile,” became one of the most-played songs of 2025 on B.B. King’s Bluesville on SiriusXM and continues to receive regular rotation, introducing Santini’s music to audiences across the country. Santini’s music has also gained increasing visibility through national television placements on CBS's Yellowstone spinoff Marshals and Fire Country, as well as Paramount Plus's Tulsa King, adding to a growing list of placements that continue to expand his reach beyond the stage. With more than 25 years of international touring, eleven career Blues Music Award nominations, and a reputation built on powerful live performances and deeply rooted songwriting, Brandon Santini remains a driving force in modern blues and Americana. ​ 7 Blues Music Award Nominations 3 Time BILLBOARD Charting Artist Endorsed by Hohner Harmonicas