Cork Seminar: From Longevity to Precision Healthy Ageing

Pure Encapsulations Seminar Series From Longevity to Precision Healthy Ageing: A Structured Evidence-Based Approach to Clinical Assessment and Intervention Longevity science is moving from the search for individual “anti-ageing” interventions towards understanding why people age differently and how this knowledge might extend health span. Genetics, epigenetics, nutrition and lifestyle interact with key ageing pathways involving mTOR, AMPK, sirtuins, autophagy, mitochondrial function and inflammation. Crucially, many of these pathways respond to diet and lifestyle, creating opportunities to personalise healthy-ageing strategies according to individual biology. This idea underpins precision nutrition for healthy ageing, which aims to combine genomic, metabolomic and microbiome information with targeted dietary interventions. Biological ageing measures, including DNA methylation-based epigenetic clocks, could also help assess responses. However, making a biological-age marker appear “younger” is not necessarily the same as improving healthspan. These tools still need to demonstrate that biomarker changes translate into meaningful outcomes such as reduced disease risk, preserved function and increase health span. The emerging picture is therefore one of precision longevity built on established prevention. Nutrition, physical activity, early detection and other preventive measures provide the foundation, with genetics, advanced biomarkers, and supplements layered on according to individual need and strength of evidence. Rather than replacing conventional prevention, precision tools may ultimately help make it more targeted Learning objectives: • Review how genes, lifestyle and environment influence the biology of ageing. • Identify key ageing pathways influenced by nutrition and lifestyle medicine. • Recognise the potential and limitations of assessments including nutritional biomarkers, biological hallmarks of aging, and biological-age clocks. • Explore a structured, evidence-based approached to assessment and management featuring personalised nutrition and lifestyle medicine. • · Critique the evidence for current nutritional and lifestyle approaches used in healthy-ageing strategies, including dietary supplements and dietary trends. All attendees receive • 2-hours of CPD approved education • Lecture notes • Supplementary research papers • Dinner and drinks • Free sample products Expert Speaker: Benjamin I. Brown, ND Ben is founder and director of the Nutritional Medicine Institute, an educational advocacy and research group committed to advancing the science and practice of nutritional medicine. An internationally acclaimed lecturer, Ben is host of Positive Health Podcast, on the academic advisory board and a guest lecturer at BCNH College of Nutrition and Health, and regularly speaks at major educational institutions and international conferences for health professionals. Ben is a consultant for Pure Encapsulations. He is editor of the Nutritional Medicine Journal, contributing editor of Integrative Healthcare and Applied Nutrition Magazine, on the editorial board for Nutrition Evidence, author of The Digestive Health Solution, has contributed textbook chapters, and had research published in journals including Gastrointestinal Disorders, Alternative Therapies Health and Medicine, Nutrients, and Nutrition Reviews.